RNA Biochemistry

Department of Biology, Chemistry, Pharmacy
Faculty of Chemistry and Biochemistry

please see website

In our work we address the fundamental question how alternative splicing regulates cellular function and identity; our main model systems are the mammalian circadian clock and T cell activation. In addition to its functionality we investigate mechanisms behind signal-induced, cell type specific and circadian alternative splicing. Furthermore, comparing splicing patterns between different species led to our interest in connecting alternative splicing and evolution. We employ a variety of techniques ranging from bioinformatics to RNA-protein interaction assays, in vitro splicing, minigenes and cell culture and mouse models.